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KMID : 0380620100420030350
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Korean Journal of Food Science and Technology
2010 Volume.42 No. 3 p.350 ~ p.354
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Immunomodulating Activity of Laminaria japonica Polysaccharides
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Ryu Deok-Seon
Oh Seung-Min
Kim Ki-Hoon
Kim Soo-Hwan
Choi Hyun-Ju
Lee Dong-Seok
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Abstract
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Laminaria japonica polysaccharides (LP) were prepared from L. japonica through hot water extraction, ultrafiltration and gel chromatography. In this study, we investigated the immunomodulating activity of LP (0.25-1 mg/mL) on the mitogen/alloantigen reactive proliferation and killing activity of the Balb/c mouse splenocytes. The LP directly induced the proliferation of splenocytes that was stimulated with mitogen or alloantigen in a dose-dependent manner. The killing activity of cytotoxic T lymphocytes (CTLs) and lymphokine activated killer cells (LAKs) were enhanced significantly in the LP treated cells. Also, the treatment of splenocytes with LP increased production of interleukin-2 (IL-2). These results suggest that polysaccharides from L. japonica show a substantial immunomodulating activity in mouse immune cells.
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KEYWORD
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Laminaria japonica, polysaccharides, immunomodulating activity
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